The preeminent reason to proclaim the Gospel is for souls to hear the Word. This goal leads to a singular concentration of effort on and expectation from the hearers of the Word.
There is also a Spiritual response beyond the souls. Preaching tears down spiritual strongholds. Like when Israel marched around Jericho 7 times and the walls fell down preaching likewise tears down the spiritual walls of opposition.
Paul writes in 2 Corinthians 10:4, “For the weapons of our warfare are not of the flesh but have divine power to destroy strongholds.” Thus often the first need in a new area is the tearing down of strongholds. Your preaching is the means to that end. So preach long and often and don’t be discouraged though no one responds. Your mission may be to tear down the strongholds for others to enter in. You see this dynamic when one preacher begins preaching often others eventually follow. But the first preacher needed to go in to tear down the strongholds for those who followed.